Scientist/Senior Scientist In vivo Immuno-Oncology

Asgard Therapeutics AB

Lund, Skåne
Tillfälligt
Heltid

21 timmar sedan

Om jobbet:About Asgard TherapeuticsAsgard Therapeutics is a privately held biotech company pioneering in vivo direct cell reprogramming for cancer immunotherapy, backed by Johnson & Johnson Innovation - JJDC, Inc., RV Invest, Novo Holdings, Boehringer Ingelheim Venture Fund, and Industrifonden. Our lead candidate, AT-108, is a first-in-class gene therapy that reprograms tumor cells into antigen-presenting dendritic cells (cDC1), triggering a personalized and potent anti-tumor immune response.Position OverviewThe ideal in vivo scientist candidate will have a background in immuno-oncology and hands-on experience in in vivo research. The role will involve executing in vivo and in vitro experiments, analyzing data, troubleshooting technical issues, and contributing to ongoing projects. Strong interpersonal, verbal, and written communication skills are required. Experimental rigor, scientific curiosity, and the ability to work in a fast-paced environment, adapting to evolving priorities, are musts.Key responsibilities

Conduct in vivo studies using syngeneic and CDX mouse models to evaluate biodistribution, therapeutic efficacy, and safety.
Perform immunological assays including flow cytometry, ELISpot, T-cell co-culture assays, and cytokine profiling.
Analyze and summarize data in reports and communicate findings to Asgard's R&D and executive leadership team.
Assist in experiment planning, execution, and documentation according to standard protocols.

Qualifications

PhD degree in Immunology, Cancer Biology, Biomedicine, or a related life science discipline.
Hands-on experience with in vivo mouse work in an academic or industry setting.
Basic understanding of cancer immunotherapies is critical, knowledge of dendritic cell and T cell biology is a plus.
Experience in tumor biology-related in vitro assays, including multi-color flow cytometry for ELISpot and T-cell cytotoxicity assays.
Experience with small molecule and viral vectors handling and their in vivo administration is a plus.
Felasa B or equivalent animal handling certification is required.
Strong organizational skills and ability to work in a team-oriented environment.
Good written and verbal communication skills in English.

Literature

Ascic E, at al. In vivo dendritic cell reprogramming for cancer immunotherapy. Science 386, eadn9083 (2024). DOI:10.1126/science.adn9083
Zimmermannova O, et al. Restoring Tumor Immunogenicity with Dendritic Cell Reprogramming. Science Immunology 8, eadd4817 (2023). DOI: 10.1126/sciimmunol.add4817

ApplicationPlease email your CV, cover letter and contact information for two references to to apply. Asgard will review applications on a rolling basis and only shortlisted candidates will be contacted.

Asgard Therapeutics AB

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