Postdoctoral Researcher in Chromatin Biology of Immune Cells (scholarship)
Karolinska Institutet
- Solna, Stockholm
- Permanent
- Heltid
The candidate will greatly benefit from this interdisciplinary environment, immersion in a highly stimulating and supportive research community, unique infrastructure, a buzzing capital, and scenic nature at your doorstep.Your missionThe Baranello Lab - Drawing from our expertise in the fields of topoisomerase and cancer biology, we aim to answer fundamental questions about how transcription, replication and DNA topology are functionally coordinated in human cells. We use state-of-the-art approaches to assess transcriptomic, epigenomic and replisomic profiles, as well as advanced microscopy and drug screens to understand how topoisomerase regulation affects fundamental nuclear processes (key lab references: Baranello et al. Cell 2016; Wiegard et al. Molecular Cell 2021; Das et al. Molecular Cell 2022; Cameron et al. Science Advances 2023). The overall aim is to reveal novel cancer therapy targets and improved strategies for personalized treatment.Recently we have identified a protein complex called “the topoisome” in which the oncoprotein MYC recruits and increases the catalytic activities of both Topoisomerase 1 and 2 to promote high transcriptional rates (Das et al. Molecular Cell 2022). The successful candidate will play a leading role in a full-time research project funded by the European Research Council Consolidator Grant, focused to address the key role of MYC-driven topoisome during B cells development. The outcome of this will inspire a new strategy to target MYC in lymphomas.
The project is a combination of practical laboratory tasks including master molecular biology, genomics, CRISPR-based genome editing, and computational analysis. The postdoc will plan and execute experiments, analyze data, interpret, and present the results, supervise students as well as write scientific articles, initially under partial supervision but with greater independence going forward.We are a young and dynamic research team with a well-established collaborative network. The group is also associated to the laboratory of Dr. Levens at the National Institutes of Health (US) and Dr. Shiraige at Tokyo University (JP). The successful applicant will thus be part of multiple networks of recognized scientists.Entry requirementsScholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent. A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.We are looking for a highly motivated, driven, enthusiastic person interested in our area of research, and ready to explore new avenues in science. The candidate should have a strong collaborative approach to research, be a team player as capable of performing tasks independently and contribute to a good social environment in the laboratory.The candidate must have a PhD in medical sciences, molecular biology, molecular immunology, biochemistry or equivalent.Requirements:
- Strong expertise in cell and molecular biology
- Expertise in genomics
- Expertise in transcription regulation
- Expertise in DNA topology
- Proficiency in scientific programming (e.g., R/Bioconductor, Python, UNIX)
- Interest in solving intricate scientific questions and willingness to help PhD/master students.
- Excellent interpersonal and communication skills (in English written and verbal). Emphasis will be also placed on personal suitability, fitting well into the current research group.
- A complete curriculum vitae (max 3 pages)
- A complete list of publications
- A letter describing previous accomplishments, technical expertise and why you want to work with us (no more than one-page, generic letters not accepted)
- Names and contact details of two scientists for reference letters